The venom of the K’gari funnel web spider contains a peptide that can prevent a lack of oxygen from killing cells. Image credit:Bastian Rast; The University of Queensland’s Institute for Molecular Bioscience Spiders can take down a wide range of prey items through their pharmacologically complex venoms; conservative predictions place the total number of bioactive…
A new type of gene drive can render mosquitoes resistant to malaria infection. Mosquito larvae carry naturally occurring variants of the Refre1 gene that are either susceptible (pink or yellow) or refractory to parasite infection (blue). Image credit:Zhiqian Li, Bier lab, UCSD From insecticides to vaccines, scientists have developed a range of approaches to combat…
The promise of tumor-infiltrating lymphocytes (TIL) therapy is expanding beyond melanoma to a wide range of solid tumors, but the path to clinical success remains complex. Variability in tumor tissue processing, limited lymphocyte yields, and high production costs continue to slow translation. Most manufacturing workflows still rely on multiple open and manual steps, contributing to…
Leica Biosystems, a global leader in anatomic and digital pathology solutions, today unveiled ChromoPlex III Triple Detection RUO, a chromogenic multiplex immunohistochemistry detection system engineered to simplify assay setup and reduce variability. ChromoPlex III is built to fit seamlessly into Leica Biosystems’ end-to-end translational research ecosystem—stain on BOND RXscan with Aperio, and analyze with HALO….
Prime editing, which does not induce double-stranded breaks in DNA, can correct AHC mutations in the brains of mice. Image credit:©iStock.com, Viktor Ahiev For babies born with alternative hemiplegia of childhood (AHC), an extremely rare and severe neurodevelopmental disorder, there may be no obvious symptoms for several months. Then the attacks begin: recurrent bouts of…
Around his second birthday, Uri Manor’s parents realized that their son had severe hearing loss. Manor, who is now an imaging scientist and organelle researcher at the University of California, San Diego (UCSD), studies the cellular and molecular mechanisms that drive hearing loss to develop new treatments for it. But his own experience with hearing…
In many treatment plans for breast cancer, radiotherapy helps eliminate leftover cancer cells after clinicians remove the bulk of the tumor in surgery. While this method helps decrease cancer recurrence, researchers don’t know how radiotherapy induces changes in surviving tumor cells.1 Additionally, because of the postoperative use of radiotherapy, researchers have not been able to…
The Stem Cell app uses Acridine Orange and Propidium Iodide (AO/PI) fluorophores for precise live and dead cell staining. Powered by proprietary DeNovix algorithms, it delivers superior accuracy and reproducibility with a quick and simple assay set up. The Apoptosis app eliminates the need for flow cytometry or laborious manual counting in the study of…
