Gut Microbes Cause Fibromyalgia-Like Symptoms in Mice

Gut Microbes Cause Fibromyalgia-Like Symptoms in Mice

Patients with fibromyalgia have distinct gut microbiomes from healthy people. This microbiota can cause chronic pain in mice. Image credit:© iStock.com, Chrischrisw Many people suffer from chronic pain due to various medical conditions. In some ailments, like arthritis or multiple sclerosis, tissue or nerve damage causes this pain. In fibromyalgia, though, this pain isn’t associated…

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Resolving Mendelian Diseases with Long-Read Multiome Sequencing

Resolving Mendelian Diseases with Long-Read Multiome Sequencing

This webinar will be hosted live and available on-demand. Tuesday, September 30th, 2025 2:00 – 3:00 PM Subtle disruptions in noncoding genomic regions frequently drive Mendelian diseases by altering chromatin architecture, regulatory activity, and other molecular pathways. However, most chromatin profiling techniques do not resolve these changes across long genomic regions. Fiber-seq, a synchronous long-read…

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Histone Modification Types and Effects

Histone Modification Types and Effects

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding epigenetic changes that may activate or inhibit gene expression by influencing a gene’s availability to the cellular transcription machinery. This article explores various types of histone modifications, their…

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Ancient Dental Plaque Unearths Prehistoric People’s Lifestyle

Ancient Dental Plaque Unearths Prehistoric People’s Lifestyle

Dental calculus preserves DNA over millennia, providing unprecedented information about the biodiversity and evolution of the human microbiome. Image credit:© Istock, microgen Millennia ago, when ancient people did not know what toothbrushes were, food particles and microbes clung stubbornly to their teeth. These plaques mineralized over time to form crusty, hard tartar. Christina Warinner is…

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